Z Zou*, JWei*, Y Chen*, Y Kang*, H Shi, F Yang, Z Shi, S Chen, Y Zhou, C Sepich-Poore, X Zhuang, X Zhou, H Jiang, Z Wen, P Jin#, C Luo#, C He#. FMRP phosphorylation modulates neuronal translation through YTHDF1. Molecular Cell 2023 83(23):4304-4317.e8

H Shi*, Y He*, Y Zhou*, J Huang, K Maher, B Wang, Z Tang, S Luo, P Tan, M Wu, Z Lin, J Ren, Y Thapa, X Tang, KY Chan, BE Deverman, H Shen, A Liu, J Liu#, X Wang#. Spatial Atlas of the Mouse Central Nervous System at Molecular Resolution. Nature 2023, 622: 552–561

H Zeng*, J Huang*, J Ren*, CK Wang, Z Tang, Y Zhou, H Shi, A Aditham, X Sui, X Wang#. Spatially Resolved Single-cell Translatomics at Molecular Resolution. Science 2023, 380 (6652), eadd3067

Q Li*, Z Lin*, R Liu*, X Tang*, J Huang, Y He, X Sui, W Tian, H Shen, H Zhou, H Sheng, H Shi, L Xiao, X Wang#, J Liu#. Multimodal charting of molecular and functional cell states via in situ electro-sequencing. Cell 2023, 186 (9): 2002-2017.e21.

A Aditham*, H Shi*, J Guo, H Zeng, Y Zhou, SD Wade, J Huang, J Liu, X Wang#. Chemically Modified mocRNAs for Highly Efficient Protein Expression in Mammalian Cells. ACS Chemical Biology 2022 Jan 7.

Y He*, X Tang*, J Huang, J Ren, H Zhou, K Chen, A Liu, H Shi, Z Lin, Q Li, A Aditham, J Ounadjela, EI Grody, J Shu, J Liu#, X Wang#. ClusterMap for multi-scale clustering analysis of spatial gene expression. Nature Communications 2021.12(1):5909

R Fang*, X Chen*, S Zhang*, Hui Shi*, Y Ye, Hailing Shi, Z Zou, P Li, Q Guo, L Ma, C He#, S Huang#. EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma. Nature Communications 2021.12(1):177.

Z Zhang*, K Luo*, Z Zou, M Qiu, J Tian, L Sieh, H Shi, Y Zou, G Wang, J Morrison, AC Zhu, M Qiao, Z Li, M Stephens#, X He#, C He#. Genetic analyses support the contribution of mRNA N6-methyladenosine (m6A) modification to human disease heritability. Nature Genetics 2020. 52(9): 939-949

G Chang*, L Shi*, Y Ye*, H Shi*, L Zeng, S Tiwary, JT Huse, L Huo, L Ma, Y Ma, S Zhang, J Zhu, V Xie, P Li, L Han, C He#, S Huang#. YTHDF3 induces the translation of m6A-enriched gene transcripts to promote breast cancer brain metastasis. Cancer Cell 2020. 38(6):857-871.e7.

PJ Hsu*, K Yan*, H Shi, E Izumchenko, N Agrawal#. Molecular biology of oral cavity squamous cell carcinoma. Oral Oncology 2020, 102: 104552.

PJ Hsu*, H Shi*, AC Zhu, Z Lu, N Miller, BM Edens, YC Ma#, C He#. The RNA-binding protein FMRP facilitates the nuclear export of N6-methyladenosine–containing mRNAs. Journal of Biological Chemistry 2019, 294.52: 19889-19895.

KI Zhou*, H Shi*, R Lyu, A Wylder, Ż Matuszek, JN Pan, C He, M Parisien#, T Pan#. Regulation of co-transcriptional pre-mRNA splicing by m6A through the low-complexity protein hnRNPG. Molecular Cell 2019, 76.1: 70-81

H Shi*, J Wei*, C He#. Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers (Review). Mol. Cell 2019, 74(4):640-650.

X Wang*#, Y Li*, W Chen, H Shi, AM Eren, A Morozov, C He, G-Z Luo#, T Pan#. Transcriptome-wide reprogramming of N6-methyladenosine modification by the mouse microbiome. Cell Research 2019, 29:167–170

H Shi*, X Zhang*, Y-L Weng*, Z Lu, Y Liu, Z Lu, J Li, P Hao, Y Zhang, F Zhang, Y Wu, JY Delgado, Y Su, MJ Patel, X Cao, B Shen, X Huang, G-l Ming, X Zhuang, H Song#, C He#, T Zhou#. m6A facilitates hippocampus-dependent learning and memory through YTHDF1. Nature 2018, 563: 249-253.

PJ Hsu, Q Fei, Q Dai, H Shi, D Dominissini, L Ma, C He#. Single base resolution mapping of 2’-O-methylation sites in human mRNA and in 3’terminal ends of small RNAs. Methods 2018, 156:85-90.

M Li*, X Zhao*#, W Wang, H Shi, Q Pan, Z Lu, SP Perez, R Suganthan, C He, M Bjørås#, A Klungland#. Ythdf2-mediated m6A mRNA clearance modulates neural development in mice. Genome Biology 2018, 19(1):69.

J Wei*, F Liu*, Z Lu, Q Fei, Y Ai, PC He, H Shi, X Cui, R Su, A Klungland, G Jia, J Chen, C He#. Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm. Molecular Cell 2018, 71(6): 973-985.e5.

Z Li, P Qian, W Shao, H Shi, XC He, M Gogol, Z Yu, Y Wang, M Qi, Y Zhu, JM Perry, K Zhang, F Tao, K Zhou, D Hu, Y Han, C Zhao, R Alexander, H Xu, S Chen, A Peak, K Hall, M Peterson, A Perera, JS Haug, T Parmely, H Li, B Shen, J Zeitlinger, C He, L Li#. Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion. Cell Research 2018, 28(9): 904

JL Koranda, L Dore, H Shi, MJ Patel, LO Vaasjo, MN Rao, K Chen, Z Lu, Y Yi, W Chi, C He#, X Zhuang#. Mettl14 is essential for epitranscriptomic regulation of striatal function and learning. Neuron 2018, 99: 283-292.e5

H Huang*, H Weng*, W Sun*, X Qin*, H Shi*, H Wu, BS Zhao, A Mesquita, C Liu, CL Yuan, Y-C Hu, S Hüttelmaier, JR Skibbe, R Su, X Deng, L Dong, M Sun, C Li, S Nachtergaele, Y Wang, C Hu, K Ferchen, KD Greis, X Jiang, M Wei, L Qu, J-L Guan, C He#, J Yang#, J Chen#. Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation. Nature Cell Biology 2018, 20: 285–295.

H Shi, C He#. Phasing Gene Expression: mRNA N6-Methyladenosine Regulates Temporal Progression of Mammalian Cortical Neurogenesis (Viewpoints). Biochemistry 2018, 57 (7): 1055–1056.

H Weng*, H Huang*, H Wu*, X Qin*, BS Zhao*, L Dong*, H Shi, JR Skibbe, C Shen, C Hu, Y Sheng, Y Wang, M Wunderlich, B Zhang, LC Dore, R Su, X Deng, K Ferchen, C Li, M Sun, Z Lu, X Jiang, G Marcucci, JC Mulloy, J Yang, Z Qian, M Wei#, C He#, J Chen#. METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification. Cell Stem Cell 2018, 22(2): 191-205.e9

PJ Hsu, H Shi, C He#. Epitranscriptomic influences on development and disease (Review). Genome Biology 2017,18: 197.

RR Edupuganti*, S Geiger*, RGH Lindeboom*, H Shi*, PJ Hsu, Z Lu, SY Wang, MPA Baltissen, PWTC Jansen, M Rossa, M Müller, HG Stunnenberg, C He#, T Carell#, M Vermeulen#. N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis. Nature Structural & Molecular Biology 2017, 24: 870–878.

PJ Hsu*, Y Zhu*, H Ma*, Y Guo*, X Shi, Y Liu, M Qi, Z Lu, H Shi, J Wang, Y Cheng, G Luo, Q Dai, M Liu, X Guo, J Sha, B Shen, C He. Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesis. Cell Research 2017, 27: 1115–1127.

H Shi*, X Wang*, BS Zhao, Z Lu, H Ma, PJ Hsu, C Liu, C He#. YTHDF3 facilitates translation and decay of the N6-methyladenosine-modified RNA. Cell Research 2017, 27: 315–328.

C Qi, H Shi, P Ye, L Li, Q Qu, G Sun, G Su, Z Lu, Y Huang, C-G Yang, AD Riggs, C He#, Y Shi#. m6A RNA methylation regulates the self-renewal and tumorigenesis of glioblastoma stem cells. Cell Reports 2017, 18(11): 2622-2634.

BS Zhao*, X Wang*, AC Beadell*, Z Lu, H Shi, A Kuuspalu, RK Ho#, C He#. m6A-dependent maternal mRNA clearance facilitates maternal-to-zygotic transition in zebrafish. Nature 2017, 542: 475–478.

H Shi, C He#. A glance at N6-methyladenosine in transcript isoforms (News & Views). Nature Methods 2016, 13: 624–625.

C Li*, X Teng*, Y Qi, H Shi, B Tang, X Ma, L Lai#. Conformational Flexibility of a Short Loop near the Active Site of the SARS-3CLpro is Essential to Maintain Catalytic Activity. Scientific Reports 2016, 20918(6).

X Wang*, BS Zhao*, IA Roundtree, Z Lu, D Han, H Ma, X Weng, K Chen, H Shi, C He#. N6-methyladenosine Modulates Messenger RNA Translation Efficiency. Cell 2015, 161 (6): 1388–1399.

H Xue*, H Shi*, Z Yu*, S He*, S Liu, Y Hou, X Pan, H Wang, P Zheng, C Cui, H Viets, J Liang, Y Zhang, S Chen#, HM Zhang#, Q Ouyang. Design, Construction, and Characterization of a Set of Biosensors for Aromatic Compounds. ACS Synth. Biol. 2014, 3 (12): 1011–1014.